Olanzapine, serum or plasma

CPT: 80299

Synonyms

Zyprexa®


Expected Turnaround Time

3 days


Related Information

In-house validated method


Specimen Requirements


Specimen

Serum or plasma


Volume

2 mL


Minimum Volume

0.5 mL


Container

Red-top (no additive) tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.


Collection

Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible


Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.


Test Details


Use

Therapeutic Drug Management


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Reference Interval

10.0 - 80.0 ng/mL; Expected steady state concentrations in patients on recommended daily dosages: 10.0 - 80.0 ng/mL. Plasma concentrations of olanzapine greater than 9.0 ng/mL have been associated with therapeutic effect. Toxic range has not been established.