Hydrocodone and metabolites, serum or plasma

CPT: 80361

Synonyms

Vicodin®; Hycodan®; Lortab®; Hysingla®; Zohydro®

Test Includes

Hydrocodone; Hydromorphone; Dihydrocodeine

Expected Turnaround Time

3 days

Related Information

In-house validated method

Specimen Requirements


Specimen

Serum or plasma

Volume

3 mL

Minimum Volume

0.6 mL

Container

Red-top (no additive) tube or green-top (heparin) tube. Gel-barrier tubes are not recommended.

Collection

Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Test Details


Use

Therapeutic Drug Management

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Hydrocodone: 10 - 100 ng/mL; Hydromorphone: 1 - 30 ng/mL; Dihydrocodeine: Not established